Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 15;113(Suppl 1):S3–S9. doi: 10.1038/bjc.2015.394

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Base-excision repair/single-strand break pathway. (A) Structure of PARP1. (B) Activation of PARP1 in response to DNA damage. After binding to damaged DNA, the enzymatic activity of PARP1 increases following a conformational change to the active site. PARP1 synthesises poly(ADP) ribose chains that alter protein function and recruit additional proteins. (C) Role of PARP1 in base excision repair. (D) Model showing recruitment of DNA repair proteins following DNA damage. Abbreviations: AD, automodification domain; BRCT, BRCA1 C-terminal domain; DBD, DNA-binding domain; HR, homologous recombination; NLS, nuclear localisation signal; WGR, tyrptophan–glycine–arginine-rich domain; Zn, zinc finger. Note: Reproduced with permission from the American Society of Clinical Oncology (© Scott et al, 2015).