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Single slice of PET (a), CT (b), registered slice (c) and co-registered PET/CT projection (d) image of the cranial half of a rat on day 4 after fatigue loading in the high displacement group. Symmetric 18F-fluoride uptake was observed in regions of higher bone turnover. More 18F-fluoride uptake was observed in the central region of the loaded forelimb (arrow) than in the unloaded forelimb. Reproduced with permission from Silva et al.69
