Table 3. Genome-wide association studies in human subjects: reported significant associations.
| Gene/trait | HSA | Blood pressure | Triglycerides | Cholesterol | Insulin sensitivity | Obesity | Other | SHR/BN-Lx variants (exon/intron/other) |
|---|---|---|---|---|---|---|---|---|
| ARHGEF3 | 3 | Obesity-related glucose increase | 14 (1/13/0) | |||||
| WNT5A | 3 | Type 2 diabetes | Coronary artery calcification | 2 (0/1/1) | ||||
| CACNA2D3 | 3 | Coronary artery calcification | 99 (0/9/90) | |||||
| CACNA1D | 3 | SBP, DBP; Hypertension | Insulin resistance | 41(8/33/0) | ||||
| SFMBT1 | 3 | Hypertension | 6 (0/1/5) | |||||
| PBRM1 | 3 | Adiponectin | 4 (1/1/2) | |||||
| STAB1 | 3 | HDL-C | Waist-hip ratio | 5 (4/1/0) | ||||
| NISCH | 3 | Waist-hip ratio | 7 (4/3/0) | |||||
| BTD | 3 | Coronary heart disease | 4 (4/0/0) | |||||
| ARHGAP22 | 10 | Diabetic retinopathy | 14 (3/9/2) | |||||
| GRID1 | 10 | LV wall thickness; Stearic acid (18:0) | 48 (1/3/44) | |||||
| NRG3 | 10 | Insulin resistance; Fasting insulin | Cardiac hypertrophy | 67 (1/66/0) | ||||
| MYO9B | 19 | Glycated hemoglobin | 4 (3/1/0) | |||||
| COMP | 19 | Hypertension (4 studies) | 2 (2/0/0) | |||||
| CILP2 | 19 | TG (3 studies) | LDL-C (2 studies) | 1 (1/0/0) | ||||
| PBX4 | 19 | TG (3 studies) | LDL-C (2 studies) | 3 (0/3/0) | ||||
| LPAR2 | 19 | Sphingolipid levels | 1 (1/0/0) | |||||
| SLC18A1 | 8 | TG (3 studies) | 1 (1/0/0) | |||||
| LPL | 8 | TG-BP bivariate | TG (>20 studies) | HDL-C (>20 studies) | Waist circumference | Metabolic syndrome | 4 (2/2/0) | |
Significant associations between features of metabolic syndrome and human genes, for genomic regions syntenic to the SHR.BN16 differential segment and showing sequence variation between the SHR and BN-Lx parental strains. Data are based on the Catalog of Published Genome-Wide Association Studies, available at: http://www.ebi.ac.uk/gwas/ (accessed on Nov 26, 2015). HSA—human chromosome, SBP—systolic blood pressure, DBP—diastolic blood pressure, TG—triglycerides, LDL-C—low density lipoprotein cholesterol, HDL-C—high-density lipoprotein cholesterol, LV—left ventricle. ARHGEF3 -Rho guanine nucleotide exchange factor 3, WNT5A—wingless-type MMTV integration site family, member 5A, CACNA2D3—calcium channel, voltage-dependent, alpha2/delta subunit 3, CACNA1D—calcium channel, voltage-dependent, L type, alpha 1D subunit, SFMBT1—Scm-like with four mbt domains 1, PBRM1—polybromo 1, STAB1—stabilin 1, NISCH—nischarin, BTD—biotinidase, SYT15—synaptotagmin XV, ARHGAP22—Rho GTPase activating protein 22, GRID1—glutamate receptor, ionotropic, delta 1, NRG3—neuregulin 3, MYO9B (myosin IXb), COMP—cartilage oligomeric matrix protein, CILP2—cartilage intermediate layer protein 2, PBX4—pre-B-cell leukemia homeobox 4, LPAR2—lysophosphatidic acid receptor 2, SLC18A1—solute carrier family 18 (vesicular monoamine transporter), member 1, LPL—lipoprotein lipase.