Table 1. Concentration and estimated amount of VEGF-Trap in the vitreous, aqueous humor, and retina of rabbits at 1 h and at 1, 2, 5, 14, and 30 days after intravitreal VEGF-Trap injection.
| Time |
Vitreous |
Aqueous humor |
Retina |
|||
|---|---|---|---|---|---|---|
| Conc (μg/ml) | Amount (μg) | Conc (μg/ml) | Amount (μg) | Conc (μg/g) | Amount (μg) | |
| 1 h | 86.2±12.7 | 129.3±19.0 | 49.5±5.3 | 9.9±1.1 | 25.6±10.2 | 0.6±0.2 |
| 1 days | 56.0±6.6 | 83.9±9.9 | 36.6±1.1 | 7.3±0.2 | 19.2±4.3 | 0.5±0.1 |
| 2 days | 46.6±1.5 | 69.9±2.2 | 14.4±1.4 | 2.9±0.3 | 8.4±6.2 | 0.2±0.1 |
| 5 days | 39.5±7.7 | 59.2±11.5 | 10.0±0.2 | 2.0±0.0 | 2.5±2.5 | 0.1±0.1 |
| 14 days | 3.4±0.2 | 5.0±0.3 | 2.1±0.3 | 0.4±0.1 | — | — |
| 30 days | 1.3±0.7 | 1.9±1.0 | 0.4±0.0 | 0.1±0.0 | — | — |