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Moderate hypoxia improves outcome in polymicrobial ALI. Animals were treated with intratracheal lipopolysaccharide (LPS) and staphylococcal enterotoxin B (SEB) to mimic polymicrobial lung injury. High oxygen concentrations led to decreased survival within 48–60 h after intratracheal injection of toxins as hyperoxia suppresses adenosine A2A receptor-mediated activation of anti-inflammatory pathways.
