Table 5.
IHC panels for small round blue cell neoplasms
| Ewing's sarcoma/ PNET | Merkel cell | Melanoma | Metastatic lung SCC | DSRCT | |
|---|---|---|---|---|---|
| Keratin | 0–50% | 80–100% | 0–10% | 100% | 69–100% |
| [146, 149, 160, 225] | [79, 147, 226, 227] | [154, 161, 162, 163, 228] | [226] | [31, 32, 153, 159] | |
| CK20 | 0% | 75–100% | 0% | 0% | 0% |
| [146] | [79, 82, 168, 226, 227, 229] | [82, 228] | [80] | [159] | |
| EMA | 16% | 95% | 0–7% | – | 90–96% |
| [160] | [168] | [154, 161, 162, 163] | [151, 152, 159] | ||
| S100 | 38% | 17–22% | 95–100% | – | 0–13% |
| [3] | [79, 82] | [82, 154, 161, 228] | [151, 152] | ||
| LCA | 0% | 0% | – | – | – |
| [230] | [79] | ||||
| Synapto 23–25% | 75–96% | – | 100% | 15–75% | |
| [3, 160] | [79, 168, 226, 227] | [226] | [151, 152, 159] | ||
| NSE | 36–88% | 100% | 30% | 58–100% | 72% |
| [3] | [82] | [82] | [231, 232, 233] | [159] | |
| PAX5 | 0% | 67–94% | 0% | 0–73% | – |
| [234] | [226, 235, 236] | [235, 237] | [226, 236] | ||
| CD99 | 91–100% | 55–100% | 57–60% | – | 0–57% |
| (MIC2) | [3, 142, 143, 144, 145, 146, 147, 148, 149] | [168, 229] | [238, 239] | [145, 151, 152, 153, 154] | |
| FLI–1 | 71–100% | 90–100% | 50–60% | – | 0–87% |
| [147, 148, 149, 150] | [155, 168] | [155, 239] | [150, 155] | ||
| TTF–1 | – | 0–12% | 0% | 90–100% | – |
| [80, 147, 226, 227] | [228] | [80, 169, 226] | |||
| NKX2.2 | 93% [157] | 0% | 33% | 25% | 0% |
| [157] | [157] | [157] | [157] | ||
Numbers in square brackets indicate references.