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. Author manuscript; available in PMC: 2016 Mar 31.
Published in final edited form as: J Biomed Nanotechnol. 2015 Nov;11(11):1859–1898. doi: 10.1166/jbn.2015.2145

Figure 6.

Figure 6

(A) Dendrimers are hyperbranched, star-link polymers. Drugs can be either conjugated to the dendrimer surface or encapsulated within “void” spaces between adjacent branches. (B) Dendrimers grow linearly in size and exponentially in surface area with each successive “generation.” They can be utilized as multifunctional nanocarriers, bearing drugs, imaging agents, and/or targeting moieties. (C) Synthesis of poly(amido amine) (PAMAM) dendrimers occurs from a ethylenediamine core with alternating reactions with methyl acrylate and ethylenediamine to produce each generation. Reprinted with permission from [278], N. Larson and H. Ghandehari, Polymeric conjugates for drug delivery. Chem. Mater. 24, 840 (2012). © 2012, American Chemical Society.

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