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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Shock. 2015 Nov;44(5):452–457. doi: 10.1097/SHK.0000000000000452

Figure 5. Proposed pathway of fresh frozen plasma's protection after hemorrhagic shock.

Figure 5

After hemorrhagic shock, ADAM-17 is increased. ADAM-17 is a known sheddase of both TNFα and syndecan-1. Additionally, TNFα is a potent sheddase of syndecan-1. Fresh frozen plasma (FFP) may directly interact with ADAM-17 to reduce its activity and/or interact with syndecan-1 to reconstitute gut epithelial cell syndecan-1 and reduce systemic syndecan-1 shedding.