Table 1.
TNFα | TNFα | ADAM-17 | ADAM-17 | |
---|---|---|---|---|
Group | WT | KO | WT | KO |
Sham | 20.9 ± 1.0 | 22.0 ± 1.3 | 1.31 ±0.06 | 1.28 ±0.07 |
HS | 38.8 ± 1.5* | 45.8 ± 0.8* | 2.67 ±0.10* | 3.43 ±0.08* |
HS-LR | 29.9 ± 0.8*# | 39.3 ± 1.2*# | 1.94 ±0.08*# | 2.37 ±0.10*# |
HS-FFP | 24.5 ± 1 .0#^ | 36.9 ± 0.8*# | 1.52 ±0.05*#^ | 2.12 ±0.11*# |
WT= wild tye; KO=knock out; HS= hemorrhagic shock; LR=lactated Ringers; FFP=fresh frozen plasma. Results are presented as ng/ml; mean±SEM, n=8/group.
p<0.01 vs sham of respective WT or KO mouse
p<0.01 vs HS of respective WT or KO mouse
p<0.01 vs LR of respective WT or KO mouse