Table 4. Multivariate analysis of the association between SNPs in Pfcrt and Pfmdr1 genes and ASAQ treatment failure.
| Crude OR | 95%CI | P-value | Adjusted OR | 95%CI | P-value | |
|---|---|---|---|---|---|---|
| Age group | ||||||
| < 5 years | 2.25 | 0.97–5.24 | 0.058 | |||
| ≥ 5 years | 1.00 | - | - | |||
| Haemoglobin level | ||||||
| <median = 9 g/dl | 1.00 | - | - | - | ||
| ≥ median = 9g/dl | 0.46 | 0.25–0.86 | 0.016 | |||
| Parasite density | ||||||
| < median = 30762 /μl | 1.00 | - | - | - | ||
| ≥ median = 30762 /μl | 1.46 | 0.78–2.73 | 0.225 | |||
| Pfcrt K76T | ||||||
| Wild | 1.00 | - | - | 1.00 | - | - |
| Mutant | 1.20 | 0.55–2.61 | 0.633 | 1.68 | 0.67–4.21 | 0.263 |
| Pfmdr1 N86Y | ||||||
| Wild | 1.00 | - | - | 1.00 | - | - |
| Mutant | 0.86 | 0.24–3.02 | 0.815 | 0.78 | 0.20–3.01 | 0.729 |
| Pfmdr1-Y184F | ||||||
| Wild | 1.00 | - | - | 1.00 | - | - |
| Mutant | 0.95 | 0.49–1.84 | 0.901 | 0.96 | 0.43–2.14 | 0.932 |