Table 3. Minimal fungicidal concentrations (mg/L) of Sporothrix spp. strains grown in presence or absence of L-DOPA or L-tyrosine.
| Strain | Amphotericin B | Itraconazole | Ketoconazole | Terbinafine | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDAa | LDb | Tyrc | PDA | LD | Tyr | PDA | LD | Tyr | PDA | LD | Tyr | |
| S. brasiliensis | ||||||||||||
| CBS 120339 | 8.0 | 4.0 | 4.0 | 4.0 | 2.0 | 4.0 | 4.0 | 4.0 | 4.0 | 0.12 | 0.12 | 0.12 |
| IPEC 26449 | 8.0 | 4.0 | 4.0 | 8.0 | 8.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 2.0 | 4.0 |
| S. schenckii | ||||||||||||
| IPEC 24372 | 8.0 | 4.0 | 8.0 | 8.0 | 8.0 | 8.0 | 2.0 | 2.0 | 2.0 | 0.5 | 4.0# | 1.0 |
| IPEC 23250 | 8.0 | 4.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 0.06 | 0.06 | 0.06 |
| ATCC 16345 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 2.0 | 1.0 | 1.0 |
| ATCC 32268 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 4.0 | 4.0 | 4.0 | 0.25 | 0.5 | 0.25 |
a PDA, potato dextrose agar
b LD, PDA supplemented with 1 mM L-DOPA
c Tyr, PDA supplemented with 10 mM L-tyrosine
#greater than one-dilution increase compared to PDA cultivated cells