Table 4. Minimal fungicidal concentrations (mg/L) of Sporothrix spp. strains to four different antifungal drugs in presence of the melanin inhibitors tricyclazole, glyphosate, or sulcotrione.
| Strain | Amphotericin B | Itraconazole | Ketoconazole | Terbinafine | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDA | Tria | Glyb | Sulc | PDA | Tri | Gly | Sul | PDA | Tri | Gly | Sul | PDA | Tri | Gly | Sul | |
| S. brasiliensis | ||||||||||||||||
| CBS 120339 | 8.0 | 2.0* | 2.0* | 2.0* | 4.0 | 1.0* | 8.0 | 8.0 | 4.0 | 2.0 | 8.0 | 2.0 | 0.12 | 0.12 | 0.12 | 0.12 |
| IPEC 26449 | 8.0 | 4.0 | 2.0* | 4.0 | 8.0 | 8.0 | 8.0 | 8.0 | 4.0 | 4.0 | 4.0 | 4.0 | 4.0 | 2.0 | 1.0* | 0.12* |
| S. schenckii | ||||||||||||||||
| IPEC 24372 | 8.0 | 8.0 | 8.0 | 4.0 | 8.0 | 8.0 | 8.0 | 8.0 | 2.0 | 8.0 | 8.0 | 8.0 | 0.5 | 2.0# | 1.0 | 0.5 |
| IPEC 23250 | 8.0 | 4.0 | 8.0 | 2.0* | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 4.0 | 0.06 | 0.12 | 0.06 | 0.06 |
| ATCC 16345 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 2.0 | 0.5* | 1.0 | 1.0 |
| ATCC 32268 | 8.0 | 8.0 | 4.0 | 8.0 | 8.0 | 8.0 | 8.0 | 8.0 | 4.0 | 8.0 | 8.0 | 4.0 | 0.25 | 1.0# | 0.25 | 0.25 |
a Tri, RPMI-1640 medium with the antifungal drugs supplemented with tricyclazole
b Gly, RPMI-1640 medium with the antifungal drugs supplemented with glyphosate
c Sul, RPMI-1640 medium with the antifungal drugs supplemented with sulcotrione
*greater than one-dilution reduction compared to PDA cultivated cells
#greater than a one dilution increase compared to PDA cultivated cells