Table 3. Cox proportional hazard regression analysis of predictive factors associated with biochemical recurrence after surgical treatment with pN1 prostate cancer patients.
| Biochemical recurrence | Univariable (unadjusted HR) | Multivariable (adjusted HR) | ||||
|---|---|---|---|---|---|---|
| Predictive factor | HR | 95% CI | P- value | HR | 95% CI | P- value |
| PSA | 1.00 | 0.99–1.01 | 0.968 | |||
| Pathologic Gleason score ≥8 | 2.19 | 1.21–3.97 | 0.01 | 2.40 | 1.32–4.38 | 0.004 |
| Lymphovascular invasion | 1.08 | 0.64–1.82 | 0.77 | |||
| Perineural invasion | 1.88 | 0.92–3.84 | 0.081 | 1.06 | 0.60–1.87 | 0.835 |
| Extracapsular invasion | 1.26 | 0.67–2.37 | 0.463 | |||
| Seminal vesicle invasion | 1.35 | 0.81–2.23 | 0.248 | |||
| Positive surgical margin | 1.51 | 0.88–2.57 | 0.135 | |||
| Tumor volume | 1.02 | 0.99–1.05 | 0.317 | |||
| PSA nadir | 1.02 | 0.91–1.13 | 0.79 | |||
| Early PSA persistence PSA≥0.1 ng/ml at 6 weeks after surgery |
1.10 | 0.60–2.01 | 0.76 | |||
| Lymph node yield | 1.00 | 0.97–1.02 | 0.852 | |||
| Positive lymph node, no. | ||||||
| 1 (reference) | Ref | Ref | Ref | Ref | Ref | Ref |
| ≥2 | 1.94 | 1.15–3.26 | 0.012 | 2.20 | 1.30–3.72 | 0.003 |
HR = hazard ratio; CI = confidence interval; PSA = prostate-specific antigen; ref = reference.