Table 4. Cox proportional hazard regression analysis of predictive factors associated with distant metastasis after surgical treatment with pN1 prostate cancer patients.
| Distant metastasis | Univariable (unadjusted HR) | Multivariable (adjusted HR) | ||||
|---|---|---|---|---|---|---|
| Predictive factor | HR | 95% CI | P- value | HR | 95% CI | P- value |
| PSA | 1.01 | 0.99–1.02 | 0.728 | |||
| Pathologic Gleason score ≥8 | 1.05 | 0.31–3.56 | 0.934 | |||
| Lymphovascular invasion | 1.82 | 0.82–4.08 | 0.094 | 1.93 | 0.86–4.37 | 0.115 |
| Perineural invasion | 0.58 | 0.17–1.98 | 0.384 | |||
| Extracapsular invasion | 1.49 | 0.56–3.97 | 0.426 | |||
| Seminal vesicle invasion | 0.94 | 0.44–2.01 | 0.875 | |||
| Positive surgical margin | 1.27 | 0.54–2.99 | 0.587 | |||
| Tumor volume | 1.04 | 0.98–1.10 | 0.206 | |||
| PSA nadir | 0.94 | 0.69–1.29 | 0.716 | |||
| Early PSA persistence PSA≥0.1 ng/ml at 6 weeks after surgery |
0.83 | 0.34–2.07 | 0.831 | |||
| Lymph node yield | 0.77 | 0.31–1.93 | 0.576 | |||
| Positive lymph node, no. | ||||||
| 1 (reference) | Ref | Ref | Ref | Ref | Ref | Ref |
| ≥2 | 1.05 | 1.01–1.10 | 0.034 | 1.06 | 1.01–1.11 | 0.029 |
HR = hazard ratio; CI = confidence interval; PSA = prostate-specific antigen; Ref = reference.