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. 2016 Mar 31;11(3):e0151649. doi: 10.1371/journal.pone.0151649

Fig 4. Tangeretin counteracts cisplatin-induced apoptotic changes of Bax and Bcl-2 in protein expression in rat liver.

Fig 4

(A) Western blot analysis showed the expression levels of Bax and Bcl-2 in liver tissues after the indicated treatments. (B) Relative expression levels of Bax and Bcl-2. The amount of immunoblotted proteins was quantitated by densitometry and normalized to that of β-actin. Columns, mean; bars, ± SD (n = 3 independent experiments). (C) Relative caspase 3/7 activity in liver tissues after the indicated treatments. Columns, mean; bars, ± SD (n = 4 independent values). Statistical analysis was carried out by using one way analysis of variance (ANOVA) followed by Tukey-Kramer multiple comparisons test. Silymarin (100 mg/kg); Tangeretin (100 mg/kg); Cisplatin (7.5 mg/kg). *Significant difference from normal control (vehicle) group at p < 0.05, #Significant difference from cisplatin group at p < 0.05.