Fig 3. Schematic transmembrane topology of hTAAR 1.

(Adapted from [35].) Amino acid residues incorporated in the transmembrane domains are shaded in gray, residues putatively involved in ligand binding are colored red. N-linked glycosylation at N 10 and N 17, as well as the disulfide bridge linking C 96 and C 182, is indicated according to the annotation in Swiss Prot entry TAR1_HUMAN. Known non-synonymous SNPs in the hTAAR1 that may produce changes in receptor function are boxed in blue (as determined from NCBI SNP Database). Indicated is the amino acid change induced by the SNP as: reference amino acid, residue number, change amino acid (Term = Termination). Further details, including the SNP nucleotide change are provided in the text.