Table 1. Only recently derived BXD RIs have the SNP variant found in the current D2 mice.
Tissue or DNA from B6, D2, and the listed BXD RIs was obtained, prepared, and sequenced as described in Methods. Only the D2 inbred mouse strain and a subset of recently derived BXD RIs express a non-synonymous SNP at position 229, resulting in a threonine to proline substitution at position 77 (P77T) in the second transmembrane domain of mTAAR1. Het: heterozygous for the B6 and D2 alleles.
Taar1 SNP: rs33645709 | ACC (Thr) | CCC (Pro) |
---|---|---|
inbred lab strains | DBA/2J (D2, 2015) | C57BL/6J (B6), 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, A/J, AKR/J, BALB/cJ, BUB/BnJ, C3H/HeJ, C57BL/10J, C57BL/6NJ, C57BR/cdJ, C58/J, CBA/J, DBA/1J, FVB/NJ, I/LnJ, LP/J, NOD/ShiLtJ, NZB/B1NJ, NZO/HlLtJ, NZW/LacJ, SEA/GnJ, WSB/EiJ |
wild-derived strains | SPRET/EiJ, PWK/PhJ, MOLF/EiJ, CAST/EiJ | |
BXD recombinant strains | BXD106, 108, 109, 115, 121 (het), 122, 123, 125, 126, 129, 138 (het), 140 (het), 145, 146, 148, 149 (het), 150 (het), 153 (het), 160, 162 | BXD1, 2, 5, 6, 8, 9, 11,12,14–16, 18–25, 27–32, 43–45, 48, 48a, 51, 55, 56, 60, 63–66, 68–71, 73–75, 77, 79, 83, 84, 87, 89, 90, 98–102,105, 107, 110, 112, 116–120, 124, 127, 128, 130, 139, 142–144, 151, 152, 154, 165 |