Table 3. MICs (mg/L) of penicillin, ciprofloxacin, tetracycline, tigecycline, and vancomycin against clinical Bacillus and Paenibacillus isolates.
| Species(n. of strains) | PEN | CIP | TET | TGC | VCM | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| range* | 50%a | 90%a | range | 50% | 90% | range | 50% | 90% | range | 50% | 90% | range | 50% | 90% | |
| B. cereus (25) | 8 to >256 | >256 | >256 | 0.064–0.25 | 0.125 | 0.19 | 0.047–4 | 0.5 | 4 | 0.094–0.5 | 0.25 | 0.5 | 0.094–4 | 0.75 | 1 |
| B. pumilus (14) | 0.008–0.094 | 0.032 | 0.064 | 0.047–0.15 | 0.064 | 0.125 | 0.25–1 | 0.38 | 0.5 | 0.19–0.5 | 0.38 | 0.5 | 0.094–0.19 | 0.125 | 0.125 |
| B. subtilis (11) | 0.008–0.032 | 0.016 | 0.032 | 0.047–0.094 | 0.064 | 0.064 | 0.125–4 | 2 | 3 | 0.19–0.5 | 0.38 | 0.5 | 0.094–0.75 | 0.125 | 0.25 |
| B. licheniformis (5) | 0.25 to >256 | >256 | >256 | 0.047–0.064 | 0.047 | 0.064 | 0.125–2 | 0.19 | 2 | 0.094–0.5 | 0.38 | 0.5 | 0.19–0.38 | 0.19 | 0.25 |
| B. megaterium (5) | 0.047–0.125 | 0.064 | 0.125 | 0.047–0.125 | 0.094 | 0.125 | 0.19–0.38 | 0.25 | 0.38 | 0.19–0.5 | 0.38 | 0.5 | 0.094–0.19 | 0.094 | 0.19 |
| B. simplex (5) | 0.25–0.5 | 0.25 | 0.5 | 0.125–0.19 | 0.125 | 0.19 | 0.094–0.125 | 0.125 | 0.125 | 0.094–0.5 | 0.38 | 0.5 | 0.094–0.5 | 0.19 | 0.5 |
| B. mycoides (3) | 16 to >256 | >256 | 0.064 | 0.064 | 0.38–0.5 | 0.5 | 0.19–0.5 | 0.5 | 0.75 | 0.75 | |||||
| B. flexus (3) | 0.023–0.125 | 0.125 | 0.064–0.125 | 0.064 | 0.094–0.19 | 0.125 | 0.5 | 0.5 | 0.094 | 0.094 | |||||
| P. glucanolyticus (2) | 4 | 0.064–0.125 | 0.5–4 | 0.016–0.032 | 0.5 | 0.5 | |||||||||
| P. amylolyticus (1) | 0.047 | 0.032 | 0.19 | 0.032 | 0.125 | 0.125 | |||||||||
| P. lautus (1) | 32 | 0.19 | 4 | 0.19 | 0.5 | 0.5 | |||||||||
* Maximal and minimal MIC values.
a MIC at which 50% or 90% of tested isolates are inhibited. The used interpretative criteria were S: ≤0.12, R: ≥ 0.25 for PEN; S: ≤ 1.0, R: ≥ 4 for CIP; S: ≤ 4, I: = 8, R: ≥ 16 for TET; S: ≤ 0.5 for TGC, and S: ≤ 4 for VCM.