Figure 2. Behavioral tests of anxiety and locomotor activity.
(A) Left: Activity heat maps on the EPM of representative α2F/F, α2CA1KO, α2CA3KO and α2DGKO mice treated with vehicle or diazepam. Right: Percentage (Mean ± S.E.M.) of time spent in the open arms of the EPM. (B) Left: Activity heat maps on the LDB of representative α2F/F, α2CA1KO, α2CA3KO and α2DGKO mice treated with vehicle or diazepam. The dark (red) and lit (yellow) compartments of the box are outlined for ease of visualization. Right: Percentage (Mean ± S.E.M.) of time spent in the lit compartment of the LDB. (C) Mean ( ± S.E.M.) distance travelled in the open field.
DOI: http://dx.doi.org/10.7554/eLife.14120.010
Figure 2—source data 1. Raw data for elevated plus maze and light/dark box figures.
elife-14120-fig2-data1.zip (17.4KB, zip)
DOI: 10.7554/eLife.14120.011
Figure 2—figure supplement 1. Additional measures in tests of anxiety-like behavior.
(A) Left: Percentage of entries into the open arms in elevated plus maze in F/F control, α2CA1KO, α2CA3KO and α2DGKO mice bred on the C57BL/6J background. Right: Total distance travelled in the elevated plus maze. (B) Left: Percentage of time spent in the open arms, Right: Percentage of entries into the open arms in F/F control, α2CA1KO, α2CA3KO and α2DGKO mice bred on the 129x1/SvJ background. (C) Number of entries into the light compartment in light/dark box in F/F control, α2CA1KO, α2CA3KO and α2DGKO mice bred on the 129×1/SvJ background. +p<0.06, *p<0.05, **p<0.01 in comparison to the corresponding vehicle group.