Table 2.
Results of omnibus statistical tests of measured parameters in behavioral tests of anxiety and general locomotion.
| 1. Elevated Plus Maze (C57BL/6J) | ||||||
| Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects) | ||||||
| % Open Arm Time | % Open Arm Entries | Distance Travelled | ||||
| Genotype | F(3,75)=1.41 | p=0.25 | F(3,75)=0.13 | p=0.94 | F(3,75)=0.85 F(3, 69) = 1.11 | p=0.47 |
| Drug | F(1,75)=16.48 | p<0.001 | F(3,75)=2.33 | p=0.13 | F(3,75)=0.61 | p=0.44 |
| Genotype x Drug Interaction | F(3,63)=1.54 | p=0.21 | F(3,75)=1.47 | p=0.23 | F(3,75)=1.13 | p=0.34 |
| 1’. Elevated Plus Maze (129X1/SvJ) | ||||||
| Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects) | ||||||
| % Open Arm Time | % Open Arm Entries | Distance Travelled | ||||
| Genotype | F(3,55)=0.17 | p=0.92 | F(3,55)=1.59 | p=0.20 | F(3,55)=1.17 | p=0.33 |
| Drug | F(1,55)=11.49 | P=0.001 | F(1,55)=3.4649 | p=0.07 | F(1,55)=1.28 | p=0.29 |
| Genotype x Drug Interaction | F(3,55)=2.28 | p=0.09 | F(3,55)=0.50 | p=0.69 | F(3,55)=0.82 | p=0.49 |
| 2. Light / Dark Box | ||||||
| Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects) | ||||||
| % Time in Light | Entries to Light | |||||
| Genotype | F(3,73)=5.03 | p=0.003 | F(3,73)=0.84 | p=0.48 | ||
| Drug | (F(1,73)=26.00 | p<0.001 | F(1,73)=1.45 | p=0.23 | ||
| Genotype x Drug Interaction | F(3,73)=5.53 | p=0.002 | F(3,73)=2.17 | p=0.09 | ||
| 3. Open Field | ||||||
| Two-Way Factorial ANOVA; Factors: Genotype (between-subjects), Drug (between-subjects) | ||||||
| Distance Travelled | ||||||
| Genotype | F(3,56)=1.78 | p=0.16 | ||||
| Drug | F(1,56)=0.04 | p=0.84 | ||||
| Genotype x Drug Interaction | F(3,56)=0.43 | p=0.73 | ||||