Table 3. Multivariable associations between E2 groups and subclinical measures of atherosclerosis.

Groups	Mean-IMT, mm		Maximal-IMT, mm		AD, mm		cPlaque (Y/N)
	β (SE)	P value	β (SE)	P value	β (SE)	P value	OR (95%CI)	P value
Model 1
Medium E2	0.029 (0.013)	0.03	0.038 (0.015)	0.01	0.167 (0.073)	0.02	0.949 (0.599, 1.504)	0.82
High E2 - Early decline	0.0001 (0.011)	0.99	0.002 (0.012)	0.89	0.015 (0.061)	0.81	0.651 (0.443, 0.957)	0.03
High E2 - Late decline	0.011 (0.020)	0.59	0.016 (0.023)	0.49	-0.030 (0.111)	0.79	0.848 (0.421, 1.707)	0.64
Low E2	reference		reference		reference		reference
Model 2
Medium E2	0.034 (0.015)	0.03	0.038 (0.018)	0.03	0.139 (0.083)	0.10	0.709 (0.398, 1.265)	0.24
High E2 - Early decline	0.010 (0.013)	0.44	0.008 (0.015)	0.58	0.113 (0.069)	0.10	0.547 (0.338, 0.885)	0.01
High E2 - Late decline	0.014 (0.024)	0.56	0.014 (0.027)	0.60	-0.075 (0.127)	0.56	1.151 (0.483, 2.738)	0.75
Low E2	reference		reference		reference		reference
Model 3
Medium E2	0.023 (0.016)	0.15	0.029 (0.019)	0.11	0.054 (0.087)	0.53	0.687 (0.373, 1.265)	0.23
High E2 - Early decline	0.004 (0.014)	0.74	0.007 (0.016)	0.64	0.063 (0.072)	0.39	0.568 (0.341, 0.945)	0.03
High E2 - Late decline	0.014 (0.024)	0.55	0.018 (0.028)	0.51	-0.042 (0.130)	0.75	0.907 (0.372, 2.213)	0.83
Low E2	reference		reference		reference		reference

E2 groups are modeled as posterior probabilities of group membership

Model 1: Adjusted for study site, age at visit 12, ethnicity, and education

Model 2: Model 1 plus ever smoking, ever use of medications, and visit 12 BMI, systolic blood pressure, LDL-C, HDL-C, triglycerides, HOMA –IR, and physical activity

Model 3: Model 1 plus ever smoking, ever use of medications, and baseline BMI, systolic blood pressure, LDL-C, HDL-C, triglycerides, HOMA –IR, and physical activity