Table 3. Multivariable associations between E2 groups and subclinical measures of atherosclerosis.
Groups | Mean-IMT, mm | Maximal-IMT, mm | AD, mm | cPlaque (Y/N) | ||||
---|---|---|---|---|---|---|---|---|
β (SE) | P value | β (SE) | P value | β (SE) | P value | OR (95%CI) | P value | |
Model 1 | ||||||||
Medium E2 | 0.029 (0.013) | 0.03 | 0.038 (0.015) | 0.01 | 0.167 (0.073) | 0.02 | 0.949 (0.599, 1.504) | 0.82 |
High E2 - Early decline | 0.0001 (0.011) | 0.99 | 0.002 (0.012) | 0.89 | 0.015 (0.061) | 0.81 | 0.651 (0.443, 0.957) | 0.03 |
High E2 - Late decline | 0.011 (0.020) | 0.59 | 0.016 (0.023) | 0.49 | -0.030 (0.111) | 0.79 | 0.848 (0.421, 1.707) | 0.64 |
Low E2 | reference | reference | reference | reference | ||||
Model 2 | ||||||||
Medium E2 | 0.034 (0.015) | 0.03 | 0.038 (0.018) | 0.03 | 0.139 (0.083) | 0.10 | 0.709 (0.398, 1.265) | 0.24 |
High E2 - Early decline | 0.010 (0.013) | 0.44 | 0.008 (0.015) | 0.58 | 0.113 (0.069) | 0.10 | 0.547 (0.338, 0.885) | 0.01 |
High E2 - Late decline | 0.014 (0.024) | 0.56 | 0.014 (0.027) | 0.60 | -0.075 (0.127) | 0.56 | 1.151 (0.483, 2.738) | 0.75 |
Low E2 | reference | reference | reference | reference | ||||
Model 3 | ||||||||
Medium E2 | 0.023 (0.016) | 0.15 | 0.029 (0.019) | 0.11 | 0.054 (0.087) | 0.53 | 0.687 (0.373, 1.265) | 0.23 |
High E2 - Early decline | 0.004 (0.014) | 0.74 | 0.007 (0.016) | 0.64 | 0.063 (0.072) | 0.39 | 0.568 (0.341, 0.945) | 0.03 |
High E2 - Late decline | 0.014 (0.024) | 0.55 | 0.018 (0.028) | 0.51 | -0.042 (0.130) | 0.75 | 0.907 (0.372, 2.213) | 0.83 |
Low E2 | reference | reference | reference | reference |
E2 groups are modeled as posterior probabilities of group membership
Model 1: Adjusted for study site, age at visit 12, ethnicity, and education
Model 2: Model 1 plus ever smoking, ever use of medications, and visit 12 BMI, systolic blood pressure, LDL-C, HDL-C, triglycerides, HOMA –IR, and physical activity
Model 3: Model 1 plus ever smoking, ever use of medications, and baseline BMI, systolic blood pressure, LDL-C, HDL-C, triglycerides, HOMA –IR, and physical activity