Figure 2. HIV-specific activity of IgG antibodies in CVL and plasma.
IgG binding antibodies were measured in CVL and plasma from the 7 CAPRISA 002 women who developed broadly cross neutralizing antibodies. Dots represent CVL and plasma samples from 1 year (red), 2 years (green) and 3 years (blue) post HIV infection. Reactivity to 8 antigens was evaluated via a customized binding antibody multiplex assay (BAMA). The median fluorescence intensity (MFI) values were normalized to total IgG concentration (specific activity). Samples that had MF1<100 were considered non-responders therefore the points are not reflected on the plots. Responders had a specific activity >0.01 for all antigens.