Figure 5. Epitope mapping of antibody specificities by ELISA (A) and neutralization (B).
CVL and plasma IgG antibody specificities in CAP177 at 3 years post infection were tested by binding to wild-type and N332A mutant gp120 while MPER IgG activity in CAP206 was detected at 3 years post infection in both genital tract and plasma (A). Plasma and genital tract IgG antibody from CAP8, CAP256 and CAP255 were mapped by measuring neutralization of wild-type virus and mutant viruses. The dotted lines represent IC50 values (B).