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Osmolytes stabilize formation of the intermediate (a–c) are binned extension distributions for all transitions used for fitting from buffer (black), sorbitol (red), and TMAO (orange), respectively, for unfolded (U) and intermediate (I) states. The mean values of extension have not changed appreciably; however, the relative populations of both have changed significantly from 3.6% to 13.6% and 24.6% from buffer to sorbitol and TMAO, respectively. To see this figure in color, go online.
