Figure 1.

DNA methylation profile around the transcription start site (TSS) of ZNF154. A and B: A smoothed CpG methylation (mCpG) profile in a colon tumor sample (gray line) and adjacent normal tissue (dashed black line), obtained from whole-genome bisulfite sequencing data (A). The rug plot illustrated along the bottom of the panel marks all CpG positions (A). The TSS (vertical line, A) and the amplicon interval (gray rectangle, A) correspond to the region of the UCSC Human Genome Browser (black rectangle, B). C: Genomic positions of 20 CpGs in the 302-bp ZNF154 amplicon: enlarged view of the TSS region and partial overlap with the annotated CpG island.