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Performance of the four selected predictors (m, x, y, and z; defined in text) in distinguishing endometrial, colon, stomach, lung, and breast tumors from normal samples at different simulated dilution levels. Area under the receiver operating characteristic curve (AUC) is plotted as a function of simulated tumor DNA dilution. The leftmost AUC values (when fraction of normal DNA is 0) correspond to the data presented in Figure 7.
