Figure 1.

Overview of the structure of the ClC-ec1 antiporter and transport pathways for Cl^– (green dashed) and H⁺ (red dashed). ClC-ec1 consists of two monomers, where monomer A is colored in yellow, and monomer B is in blue. The central region is highlighted in the black box. Two pathways for Cl^– and H⁺ meet at E148. In the figure, one Cl^– is bound to S_cen site, which is very close to the H⁺ pathway. The other Cl^– binding sites (S_ext and S_int) are not shown here. To see this figure in color, go online.