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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Biochem J. 2008 Jul 15;413(2):251–259. doi: 10.1042/BJ20071496

Figure 8.

Figure 8

The intracellular transport of HAI-1 in MDCK cells. HAI-1 is from the Golgi apparatus transported mainly to the basolateral plasma membrane (A) but we can not rule out that a minor fraction is transported directly to the apical plasma membrane (B). HAI-1 is endocytosed from the basolateral plasma membrane (C) and at least partly recycled back to the basolateral plasma membrane (D). A substantial fraction of the HAI-1 molecules at the basolateral plasma membrane is transcytosed to the apical plasma membrane (E). From both the apical and the basolateral plasma membrane there is a partial proteolytic release of the HAI-1 ectodomain symbolized by a pair of scissors. A fraction of the HAI-1 molecules is eventually degraded in the lysosomes. It was not determined from which cellular compartment HAI-1 is directed to the lysosomes, but it is most likely derived from the apical plasma membrane (F), as this would account for the low steady state concentration of HAI-1 found in this compartment.