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Lack of endothelial ERα abrogates the increased in arterial stiffness induced by WD feeding. A, PWV values obtained before killing. B, Force measurements were acquired by interaction between a cantilever tip and the EC surface of aortic explants from mice. C–F, Femoral artery modulus of elasticity. Values are mean ± SE. n = 5–8 per group. Post hoc comparisons within different groups; *, P < .05 GP-CD vs GP-WD; †, P < .05 GP-WD vs EC-ERαKO-WD.
