Table 2.
Transgenic Rescue of Prop1 Mutant Mice
| Transgenic Construct | Line | Full Sized Tg; Prop1df/− Micea | Dwarf Tg; Prop1df/− Micea | Penetrant Correction |
|---|---|---|---|---|
| 25-kb Prop1 Tg | 103 | 5 | 0 | 100 |
| 114 | 6 | 0 | 100 | |
| 450 | 12 | 0 | 100 | |
| 453 | 6 | 0 | 100 | |
| 231 | 2 | 5 | 29 | |
| 241 | 1 | 0 | 100 | |
| 10-kb Prop1 Tg | 244 | 0 | 2 | 0 |
| 248 | 6 | 1 | 86 | |
| 463 | 11 | 0 | 100 | |
| 853 | 5 | 0 | 100 | |
| HsPROP1 BAC Tg | 862 | 4 | 1 | 80 |
| 868 | 4 | 0 | 100 | |
| 884 | 4 | 0 | 100 |
Each line number represents the ear tag of the founder transgenic mouse.
a
The number represents the total number of dwarf mice or transgenic dwarf mice collected over multiple litters. Only 1/8 of the mice are expected to be transgenic and compound heterozygotes for Prop1 loss of function mutations (Prop1df/−).