Figure 1.
Intrinsic network similarities in alcoholics (ALC) and controls (CTL). (a) Self-referential default mode network (DMN) (posterior cingulate cortex seed, PCC) and integrative function networks: executive control (EC) network —superior frontal gyrus (SFG) seed, salience (SA) network—anterior cingulate cortex (ACC) seed, dorsal attention (AT) network—superior parietal lobe (SPL) seed; (b) primary input function networks: somatosensory (SS) network—postcentral gyrus seed, auditory (AU) network—Heschl gyrus seed, visual (VI) network—calcarine gyrus seed; and (c) subcortical emotion and reward networks: reward (RW) —nucleus accumbens (NAcc) seed, emotion (EM) —amygdala seed. A result output image was created for each within-group analysis for each seed's connectivity map with the same statistical threshold for all analyses (combined peak-and-extent threshold with peak P < 0.001 and extent PFWE-corrected < 0.05). Brain regions showing synchronized BOLD activity with the seed are marked: red for ALC, green for CTL, and yellow when functionally connected in both groups (overlap). MNI z-coordinates indicate slice locations.