Table 2.

Results of voxelwise fMRI and percent signal change analyses in ET versus controls

Cluster no.	Side	Region(s)	Size (mm3)	Peak MNI coordinates				Pearson r-values for correlation between PSC and SD of force
				x	y	z	F-value	0–3 Hz	3–8 Hz	8–15 Hz
ET > controls
Cluster 1	Ipsi	V1*, V2	702	18	−102	−6	46.32	0.238	0.567	0.092
Cluster 2	Con	M1*	594	−26	−24	60	30.85	0.167	0.460	−0.016
Cluster 3	Con	SMA*	837	−2	−10	66	23.70	0.210	0.373	0.097
Cluster 4	Ipsi	DLPFC*	756	36	14	38	19.29	0.309	0.453	0.157
Cluster 5	Ipsi	PMd*	621	36	−10	44	19.27	−0.025	0.228	−0.088
Cluster 6	Con	Middle frontal gyrus*, middle cingulate cortex	621	−30	24	36	18.30	0.224	0.436	−0.022
Cluster 7	Con	S1*	324	−38	−36	50	14.41	0.126	0.217	−0.103
Cluster 8	Con	Inferior parietal lobule*	405	−48	−52	44	13.98	0.242	0.366	0.187
ET < controls
Cluster 1	Ipsi*, Con	Cereb lobules I-IV*	1872	6	−46	−15	25.13	−0.361	−0.159	−0.128
	Ipsi	Cereb lobule V
Cluster 2	Con	M1*, S1	128	−60	−10	20	24.38	−0.300	−0.246	0.026
Cluster 3	Con	Thalamus*, caudate	96	−18	−12	20	22.18	−0.231	−0.129	0.057
Cluster 4	Ipsi	Cereb crus II*, lobule VIIb	656	2	−76	−39	17.41	−0.316	−0.128	−0.073

Note: Con, contralateral; DLPFC, dorsolateral prefrontal cortex; ET, essential tremor; Ipsi, ipsilateral; M1, primary motor cortex; PMd, dorsal premotor area; PSC, percent signal change; S1, primary somatosensory cortex; SMA, supplementary motor area; V1/V2, primary and secondary visual cortex. All clusters significant at P < 0.05, corrected. Region at peak coordinate is noted with an asterisk. The bold values are P < 0.006, FDR corrected P < 0.05.