Table 3.
Group fMRI activation differences in ET versus PD
| Cluster no. | Side | Region(s) | Size (mm3) | Peak MNI coordinates |
|||
|---|---|---|---|---|---|---|---|
| x | y | z | F-value | ||||
| ET > PD | |||||||
| Cluster 1 | Ipsi | M1* | 432 | 34 | −12 | 66 | 40.21 |
| Cluster 2 | Ipsi | Cereb lobules VI*, V | 2592 | 20 | −60 | −25 | 39.68 |
| Cluster 3 | Con | Putamen*, GPe, insula, middle frontal gyrus, inferior frontal gyrus | 3807 | −30 | −4 | −4 | 37.19 |
| Cluster 4 | Ipsi | DLPFC*, anterior cingulate cortex, superior medial gyrus | 3510 | 28 | 38 | 26 | 33.35 |
| Cluster 5 | Con | SMA* | 351 | −8 | −18 | 56 | 33.00 |
| Cluster 6 | Con | GPe*, GPi, putamen, STN, thalamus | 1674 | −30 | −10 | −6 | 29.73 |
| Cluster 7 | Ipsi*, Con | Pre-SMA* | 1350 | 6 | 8 | 50 | 29.36 |
| Cluster 8 | Con | Middle cingulate cortex*, anterior cingulate cortex, PMd, SMA, pre-SMA | 4185 | −18 | 24 | 30 | 29.35 |
| Cluster 9 | Con | PMd*, pre-SMA | 810 | −18 | −4 | 62 | 28.25 |
| Cluster 10 | Con | Caudate* | 351 | −8 | 6 | 20 | 27.76 |
| Cluster 11 | Ipsi | Putamen*, caudate, insula, inferior frontal gyrus | 3942 | 24 | 2 | −10 | 27.25 |
| Cluster 12 | Ipsi | Middle temporal gyrus (V5)* | 486 | 46 | −70 | 8 | 26.64 |
| Cluster 13 | Con | S1*, M1 | 3834 | −48 | −36 | 50 | 26.22 |
| Cluster 14 | Con | Frontopolar cortex* | 3078 | −30 | 48 | 12 | 25.68 |
| Cluster 15 | Con | Inferior frontal gyrus* | 324 | −42 | 36 | 6 | 23.19 |
| Cluster 16 | Ipsi | Inferior parietal lobule* | 459 | 48 | −42 | 38 | 23.71 |
| Cluster 17 | Ipsi | PMv*, PMd, DLPFC | 1998 | 48 | 8 | 38 | 22.40 |
| Cluster 18 | Con | WM*, putamen | 567 | −26 | 6 | 18 | 21.00 |
| Cluster 19 | Ipsi | Thalamus*, GPe | 486 | 16 | −18 | 8 | 19.78 |
| Cluster 20 | Ipsi | GPi*, GPe, thalamus | 432 | 10 | −4 | 0 | 19.58 |
| Cluster 21 | Ipsi | Middle temporal gyrus* | 351 | 52 | −36 | 6 | 19.06 |
| Cluster 22 | Ipsi | M1*, PMd | 324 | 36 | −10 | 48 | 18.36 |
| Cluster 23 | Con | Substantia nigra* | 351 | −8 | −22 | −12 | 17.36 |
| Cluster 24 | Con | Angular gyrus* | 513 | −38 | −58 | 32 | 17.20 |
| Cluster 25 | Con | Inferior parietal lobule* | 486 | −32 | −48 | 50 | 16.49 |
| Cluster 26 | Ipsi | S1* | 351 | 48 | −22 | 30 | 15.36 |
Note; Con, contralateral; DLPFC, dorsolateral prefrontal cortex; GPe, external globus pallidus; GPi, internal globus pallidus; Ipsi, ipsilateral; M1, primary motor cortex; PD, Parkinson's disease; PMd, dorsal premotor area; PMv, ventral premotor area; S1, primary somatosensory cortex; SMA, supplementary motor area; STN, subthalamic nucleus. All clusters significant at P < 0.05, corrected. Region at peak coordinate is noted with an asterisk.