Fig. 2.

Mimicking barrier tissues of organs in microdevices. SKIN CHIP: A series of microfluidic chambers were connected to model the skin and hair follicles. A Transwell chamber contained skin biopsies placed over ex vivo subcutaneous tissue with a fluidic basolateral chamber. A fluidic chamber containing follicular hair extracts (FUEs) followed the skin chamber in circuit. Reproduced from Atac et al. (2013) with permission of The Royal Society of Chemistry. LUNG/GI CHIP: This chip design was used to model both the lung and GI barrier tissues. Two fluidic channels run in parallel with a porous membrane to separate epithelium from endothelium. Additionally, empty chambers run along the sides of this device and pull a cyclic vacuum to mimic movement due to breathing or digestion respectively in lung or GI models. GI model reproduced from Kim et al. (2012) with permission of The Royal Society of Chemistry. Lung device from [Huh, D. et al. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med, 4, 159ra147]. Reprinted with permission from AAAS.