Fig. 1.

Pgam5 knockout (KO) mice exhibit a resistance phenotype against cold stress under fasting condition. (a, b) Survival rate and body temperature of WT and Pgam5 KO mice at the indicated time periods after cold exposure combined with fasting (n = 10). (c) The body temperatures of cold-exposed WT and Pgam5 KO mice were monitored for 60 h under fed conditions (n = 4). (d, e) The survival rate (d) and body temperatures (e) of WT and Pgam5 KO mice were monitored at the indicated time periods under fasting conditions (WT; n = 6, KO; n = 5). Data are expressed as the means ± SEM, **p < 0.01, ***p < 0.001; log rank test (a), unpaired Student's t-test (b).