Subject area	Biology
More specific subject area	Bioinformatics and cell signaling
Type of data	Transcriptome, table, figure
How data was acquired	High-throughput RNA sequencing using Illumina HiSeq 2500
Data format	Raw, fastq files
Experimental factors	RNA isolation, cDNA library construction and sequencing
Experimental features	Transcriptome analysis of Cos1 cells depleted of SHOC2 using:
Cos1 cells expressing non-targeting shRNA (Cos-NT) (control; n=3);
Cos1 cells expressing SHOC2 specific shRNA (Cos-LV1) (n=3)
Data source location	Lexington, KY, USA
Data accessibility	The data is available with this article and via NCBI׳s GEO through the direct linkhttp://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSSE67063. GEO: GSE67063