Table 2.
Frequency and duration (in days) of treatment-emergent hypomanic symptoms
| Venlafaxine group (n = 65) |
Lithium group (n = 64) |
P | |
|---|---|---|---|
| Hypomania,a n (%) 95% CI | 2 (3.1) 0.0 to 8.0 | 5 (7.8) 1.7 to 15.3 | 0.27 |
| Type I,a n (%) 95% CI | 4 (6.2) 1.7 to 15.0 | 2 (3.1) 0.0 to 7.8 | 0.68 |
| Type II,a n (%) 95% CI | 8 (12.3) 5.5 to 22.8 | 5 (7.8) 3.8 to 18.8 | 0.56 |
| Type III,a n (%) 95% CI | 9 (13.8) 6.5 to 24.7 | 5 (7.8) 3.8 to 18.8 | 0.40 |
| Hypomania or type I, n (%) 95% CI | 6 (9.2) 3.5 to 19.0 | 7 (10.9) 4.5 to 21.2 | 0.78 |
| Hypomania or type I or II,c n (%) 95% CI | 13 (20.0) 11.1 to 31.8 | 12 (18.8) 10.1 to 30.5 | 1.00 |
| Any episode,c n (%) 95% CI | 19 (29.2) 18.6 to 41.8 | 13 (20.3) 11.3 to 32.2 | 0.31 |
| Duration hypomania,b mean (s.d.) 95% CI | 9.5 (7.8) −6.40 to 79.4 | 9.6 (5.3) 3.0 to 16.2 | 0.99 |
| Duration type I hypomania,b mean (s.d.) 95% CI | 2.8 (0.5) 2.0 to 3.5 | 3.0 (1.4) −9.7 to 15.7 | 0.85 |
| Duration type II hypomania,b mean (s.d.) 95% CI | 11.9 (7.1) 6.0 to 17.8 | 13.2 (13.9) −4.1 to 30.5 | 0.82 |
| Duration type III hypomania,b mean (s.d.) 95% CI | 3.0 (2.0) 1.5 to 4.5 | 2.0 (0.71) 1.1 to 2.9 | 0.31 |
| Duration hypomania or type I, mean (s.d.) 95% CI | 5.0 (4.9) −0.2 to 10.2 | 7.7 (5.4) 2.7 to 12.7 | 0.37 |
| Duration hypomania or type I or II, mean (s.d.) 95% CI | 9.6 (10.2) 3.5 to 15.8 | 10.0 (9.7) 3.8 to 16.2 | 0.92 |
| Duration any episode, mean (s.d.) 95% CI | 8.0 (9.21) 3.6 to 12.4 | 10.0 (10.44) 3.9 to 16.3 | 0.57 |
a.
P-value for comparison of proportion using Fisher's exact test.
b.
Comparison of means using Student's t-test.
c.
Some of the same patients who experienced type I or hypomanic episodes also experienced type II or type III episodes.