Table 3. Lipid peroxidation, glutathione concentration, and antioxidant enzyme activities in the liver of male rats treated with 1,3-DCP.
Items | 1,3-DCP (mg/kg) | |||
---|---|---|---|---|
0 | 27.5 | 55 | 110 | |
No. of rats | 6 | 6 | 6 | 6 |
MDA (nmol/mg protein) | 0.49±0.02a | 0.52±0.05 | 0.58±0.05** | 0.64±0.04** |
GSH (nmol/mg protein) | 3.89±0.29 | 3.61±0.24 | 3.13±0.56** | 2.88±0.39** |
Catalase (units/mg protein) | 50±11 | 38±9* | 35±5** | 34±6.0** |
GR (units/mg protein) | 0.72±0.06 | 0.58±0.07** | 0.50±0.05** | 0.49±0.04** |
GST (units/mg protein) | 154±14 | 111±13** | 92±18** | 53±17** |
aValues are expressed as mean±SD. *P<0.05 versus control group. **P<0.01 versus control group.
1,3-DCP: 1,3-dichloro-2-propanol; MDA: malondialdehyde; GSH: reduced glutathione; GR: glutathione reductase; and GST: glutathione S-transferase.