Table 4. Association between LEP G2548A and LEPR Gln233Arg polymorphisms and gestational diabetes mellitus.
| GDM group n (%) | NGT group n (%) | OR (95% CI) | P | P trend | |
|---|---|---|---|---|---|
| LEP G2548A | |||||
| Allele | |||||
| A | 493 (71.04) | 522 (75.00) | 1 | 0.10 | |
| G | 201 (28.96) | 174 (25.00) | 1.22 (0.96–1.55) | ||
| Genotype | 0.09 | ||||
| AA | 172 (49.57) | 195 (56.03) | 1 | ||
| AG | 149 (42.94) | 132 (37.93) | 1.20 (0.86–1.66) | 0.28 | |
| GG | 26 (7.49) | 21 (6.03) | 1.41 (0.74–2.66) | 0.30 | |
| AG + GG | 175 (50.43) | 153 (43.96) | 1.23 (0.90–1.68) | 0.20 | |
| LEPR Gln233Arg | |||||
| Allele | |||||
| Gln | 628 (88.95) | 628 (89.20) | 1 | 0.88 | |
| Arg | 78 (11.05) | 76 (10.80) | 1.03 (0.73–1.43) | ||
| Genotype | 0.15 | ||||
| Gln/Gln | 280 (79.32) | 277 (78.69) | 1 | ||
| Arg/Gln | 68 (19.26) | 74 (21.02) | 0.91 (0.62–1.34) | 0.64 | |
| Arg/Arg | 5 (1.42) | 1 (0.28) | 5.21 (0.58–46.93) | 0.14 | |
| Arg/Gln + Arg/Arg | 73 (20.68) | 75 (21.30) | 0.97 (0.66–1.42) | 0.87 | |
†ORs and 95% CIs were calculated by logistic regression after adjusting for age and BMI. P trends were calculated by Cochran-Armitage test.