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. 2016 Feb 2;291(14):7373–7385. doi: 10.1074/jbc.M115.710186

FIGURE 8.

FIGURE 8.

Proposed mechanism of CNV development related to Angptl2. Initially, RPE and/or choroid including endothelial cells in the early lesion secrete Angptl2 and MCP-1, both of which in turn recruit macrophages. MCP-1 is at least partly regulated by Angptl2. These macrophages also secrete Angptl2, resulting in the recruitment of additional macrophages. Then Angptl2 derived from both macrophages and RPE and/or choroid induces the expression of inflammatory mediators in macrophages, and these mediators contribute to CNV development. Angptl2 might act in an autocrine and/or paracrine fashion to activate surface-bound integrin α4 and/or β2 and intracellular NF-κB and ERK pathways in macrophages.