FIGURE 1.

Potential phosphorylation sites in the C-terminal regions of CERS2–6. The schematic illustration of mammalian CERS1–6 denotes the five predicted transmembrane segments and the TRAM/LAG1/CLN8 (TLC) homology domain (45), shown as black and gray regions, respectively. The region around the potential phosphorylation sites is shaded, and the amino acid sequences of human CERS1–6 and mouse Cers1–6 in the region are presented below it. Amino acid residues analyzed in this study are highlighted in black or gray boxes, with the former denoting CK2 phosphorylation sites. For comparison, amino acid sequences and phosphorylation sites in the C-terminal region of yeast Lac1 and Lag1 are presented (27).