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. 2016 Feb 3;291(14):7637–7650. doi: 10.1074/jbc.M115.701417

FIGURE 9.

FIGURE 9.

Solution structure of the Nedd4 WW2 domain in the presence of the Cx43CT276–289(Ser(P)279, Ser(P)282) peptide. A, two different views of the 10 lowest energy structures of the WW2 domain (black) in complex with the Cx43CT276–289(Ser(P)279, Ser(P)282) peptide (red) overlaid according to the WW2 backbone atoms. Only WW2 residues Gly408–Lys432, excluding the disordered N- and C-terminal residues, are shown. B, top panel, shows two close-up views, 45° apart according to the y axis, of the binding site between the Nedd4 WW2 domain (residues Tyr419–Ser431 are represented; lilac) and the Cx43CT276–289(Ser(P)279, Ser(P)282) peptide (residues Ser279–Tyr286 are represented; green). Residues directly involved in the interaction are labeled, and their side chains are shown. The bottom panel is the surface representation with the same illustrated residues and angles as the top panel (WW2 residues Tyr408–Lys432) showing the fitting of the peptide into the XP groove.