FIGURE 9.

B. melitensis mutants defective in the core lateral branch are attenuated in dendritic cells and in mice. Bone marrow-derived dendritic cells were infected with B. melitensis 16M (wild type strain; Bm_wt) or B. melitensis 16MΔwadC (Bm_wadC), and CFU were measured at the indicated times (each point represents the means ± S.E. of triplicate wells of a representative experiment) (A). Groups of five mice were infected with 5 × 10⁴ CFU of Bm_wt (▾) or Bm_wadC (▴) and CFU/spleen determined at 2 (B) and 8 (C) weeks.