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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Curr Stem Cell Rep. 2016 Feb 13;2(1):33–42. doi: 10.1007/s40778-016-0034-8

Figure 2.

Figure 2

Effects of PRP on stem cell proliferation, differentiation potential and bone healing. (A) Effect of different PRP concentrations on the proliferation of bone-marrow derived MSCs [41]. (B) Three-dimensional micro-CT of a bone defect implanted with hydrogels containing either PBS or PRP [84]. (C) Differentiation media supplemented with PRP, bone marrow and adipose derived MSCs exhibit strong differentiation potential towards osteogenic (Alizarin Red S, calcium deposits) and chondrogenic (Toluidine Blue, glycosaminoglycans), but not adipogenic (Oil Red O, lipid accumulation). (Figure 1A Reprinted from: Amable PR, Teixeira MV, Carias RB, et al. Mesenchymal stromal cell proliferation, gene expression and protein production in human platelet-rich plasma-supplemented media. PloS one 2014;9:e104662) [41]. (Figures 1B and 1C Reprinted from: Kim YH, Furuya H, Tabata Y. Enhancement of bone regeneration by dual release of a macrophage recruitment agent and platelet-rich plasma from gelatin hydrogels. Biomaterials 2014;35:214-24, with permission from Elsevier) [84].

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