Figure 5.
Application of MSCs, PRP and hyaluronic acid in papilla regeneration in patients with Black Triangle defect. (A) Schematic depiction of the preparation and injection procedure. (B) Photographs that visualize the defect’s healing during i) pretreatment, ii) treatment, iii) 3, iv) 6, v) 12, and vi) 36 months post treatment. (Reprinted from: Yamada Y, Nakamura S, Ueda M, et al. Papilla regeneration by injectable stem cell therapy with regenerative medicine: long-term clinical prognosis. Journal of Tissue Engineering and Regenerative Medicine 2015;9:305-9, with permission from Wiley) [80].