Table 1.
Comparison of antimicrobial efficacy (MIC50 and MIC90 values) of solithromycin vs. four other relevant antibiotics against a range of important bacteria.
| Organism (number of strains) | Solithromycin | Macrolidesa | Levofloxacin | Penicillinsb | Doxycyclin | Reference | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | # | |
| Streptococcus pneumoniae (1363) | <30 | 120 | <250 | >2,000(Er) | 1,000 | 1,000 | <30 | 2000(P) | (67) | ||
| Streptococcus pyogenes (124) | 60 | 500 | 8,000 | >64,000(Az) | 500 | 1000 | 15 | 15(AC) | (76) | ||
| Streptococcus agalactiaec (GBS)R (62) | 30 | 125 | >8,000 | >8,000(Az) | (59) | ||||||
| Streptococcus agalactiaec (GBS)S (10) | 8 | 15 | <125 | <125(Az) | 32 | 47(P) | (59) | ||||
| Staphylococcus aureus (4729) | 60 | >4000 | >2,000 | >2,000(Er) | <500 | >4,000 | 1,000 | >2,000(O) | (67) | ||
| Coagulase-neg Staph. (CoNS) (862) | 60 | >4,000 | >2,000 | >2,000(Er) | 4,000 | >4,000 | >2,000 | >2,000(O) | (67) | ||
| Haemophilus influenzae (150) | 1,000 | 2,000 | 1,000 | 4,000(Az) | <500 | <500 | <1,000 | 2,000(AC) | (67) | ||
| Neisseria gonorrhoeae (246) | 125 | 250 | 500 | 8,000(Az) | 1,000 | 16,000(A) | (65) | ||||
| Chlamydia trachomatis (10) | 250 | 250 | 125 | 125(Az) | 60 | 60 | (77) | ||||
| Mycoplasma pneumoniae (38) | 0.03 | 0.125 | 0.25 | 0.5(Az) | 500 | 500 | 125 | 250 | (74) | ||
| Mycoplasma hominis (13) | 4 | 8 | 2,000 | 4,000(Az) | 250 | 500 | 125 | 8,000 | (74) | ||
| Mycoplasma genitalium (40) | <1 | 1,000 | 8 | >8,000(Az) | 250 | 1,000 | (61) | ||||
| Ureaplasma urealyticumd (10) | 8 | 31 | 2,000 | 4,000(Az) | 500 | 1,000 | 1,000 | 16,000 | (74) | ||
| Ureaplasma parvumd (10) | 8 | 16 | 2,000 | 4,000(Az) | 500 | 2,000 | 8,000 | 16,000 | (74) | ||
a(Er) erythromycin; (Az) azithromycin.
b(P) penicillin G; (AC) Amoxicillin–clavulanic acid; (O) oxacillin; (A) ampicillin.
cR, macrolide resistant; S, macrolide susceptible.
dMore recent data from the analysis of 100 strains of Ureaplasma spp. (U. parvum and U. Urealyticum combined) suggest that the solithromycin MIC90 is 125 ng/ml and 2000 ng/ml for azithromycin (75).
Solithromycin data are highlighted in the shaded text.