Figure 1. Workflow of GRN inference. Systems Biology Cycle of wet lab (experiment) and dry lab work: Experiments lead to RNA-Seq data, which need to be preprocessed and features have to be selected (more detailed steps are shown in grey boxes). A GRN is inferred for selected features. Predicted interactions are validated leading to more knowledge and new hypotheses. Both analysis of experimental data (data preprocessing and feature selection) and modeling (network inference) is supported by prior knowledge.