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. 2014 Dec 12;7(1):27–41. doi: 10.1038/ijos.2014.62

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Copyright © 2014 West China School of Stomatology

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Expression of TNAP and NPP1 in human teeth. In an adult human molar tooth, TNAP is found in cells near the root surface as well in the PDL space, for regions of both (a) AC and (b) CC. (c) TNAP is also expressed by odontoblasts lining the DE. (d) The strongest expression of NPP1 in the human molar is found specifically in root-lining cementoblasts of the acellular cementum, while (e) cementoblasts lining the cellular cementum and (f) odontoblasts display low level or no NPP1 localization. AC, acellular cementum; Cb, cementoblast; CC, cellular cementum; DE, dentin; NPP, nucleotide pyrophosphatase phosphodiesterase; Od, odontoblast; PDL, periodontal ligament; TNAP, tissue-nonspecific alkaline phosphatase.