Figure 1.

Advantages for the heat shock protein-90alpha (Hsp90α) lipoprotein receptor-related protein-1 (LRP-1) signaling over growth factor signaling in promoting wound healing. (1) The expression of a growth factor receptor is often restricted to limited skin cell types, whereas the Hsp90 receptor, LRP-1, is ubiquitously expressed in all skin cell types. (2) Growth factor-stimulated cell proliferation and cell migration are inhibited by the copresence of TGFβ in the wound environment. Hsp90α-induced cell migration is resistant to TGFβ inhibition. (3) Growth factors do not work well under hyperglycemia. Hsp90α stimulates skin cell migration even under hyperglycemia. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound