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Hsp90α and Hsp90β together operate a tissue repair mechanism. Schematically, when tissue is damaged, acute hypoxia triggers cells in the wound edge to secrete Hsp90α. Intracellular Hsp90β stabilizes LRP-1 and the secreted Hsp90α binds and signals through the LRP-1 receptor to promote cell migration and wound healing. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound
